meriT–1 study completes 2 years of follow up

• In this first in man study, BioMime was deployed in single de novo lesions and
   demonstrated high degree of clinical safety and efficacy
• 0% MACE (no death, MI or revascularizations) and 0% Stent thrombosis was observed
   beyond 2 years of follow-up
• 0.15mm median late lumen loss is seen at 8 months QCA

meriT-2 study on BioMime SES completes recruitment

• MeriT-2 was a multi-centric study conducted in India involving complex real world patients.
• The study enrollment of 250 patients is now complete.
• Interim data on more than 200 patients followed up beyond 1 year demonstrates an
   acceptable MACE of 7.6% and a median late loss of 0.15 mm at 8 months QCA on 97

BIOMIME Sirolimus Eluting Coronary Stent System Receives Regulatory Approvals

• Receives Indian Approval – DCG(I)January 2009

• Receives MOH Russia approval June 2010

• Receives CE markNovember 2010

• Receives ANVISA mark approvalJanuary 2011

BIOMIME Sirolimus Eluting Coronary Stent System Is Commercially Available In

• India
• Europe
• Brazil
• Russia
• Middle East
• Africa
• South East Asia
• Latin America

Meril Announces Direct Operations

In order to attend and service large markets, Meril has set up its own direct operations in Germany for Europe and Brazil for Latin America.

• Meril European Headquarters
   Meril GmbH
   Bornheimer Strasse 135 - 137
   D - 53119 Bonn Germany
   T +49 228 7100 4000
   F +49 228 7100 4001

• Meril South American Head Quarters
   1079 - Cep: 04077-003 - Moema
   Sao Paulo, Brazil
   T +55 11 9116 0159


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